There were a total of 10 head coaching changes this off-season.
| Team | Conf | 2021 Coach | Year | Latest Status | 2022 Coach |
|---|---|---|---|---|---|
| ARI | N | Kliff Kingsbury | 3rd | Kliff Kingsbury | |
| ATL | N | Arthur Smith | 1st | Arthur Smith | |
| BAL | A | John Harbaugh | 14th | John Harbaugh | |
| BUF | A | Sean McDermott | 5th | Sean McDermott | |
| CAR | N | Matt Rhule | 2nd | Matt Rhule | |
| CHI | N | Matt Nagy | 4th | Matt Eberflus | |
| CIN | A | Zac Taylor | 3rd | Zac Taylor | |
| CLE | A | Kevin Stefanski | 2nd | Kevin Stefanski | |
| DAL | N | Mike McCarthy | 2nd | Mike McCarthy | |
| DEN | A | Vic Fangio | 3rd | Nathaniel Hackett | |
| DET | N | Dan Campbell | 1st | Dan Campbell | |
| GB | N | Matt LaFleur | 3rd | Matt LaFleur | |
| HOU | A | David Culley | 1st | Lovie Smith | |
| IND | A | Frank Reich | 4th | Frank Reich | |
| JAC | A | Urban Meyer | 1st | Doug Pederson | |
| KC | A | Andy Reid | 9th | Andy Reid | |
| LV | A | Jon Gruden | 4th | Josh McDaniels | |
| LAC | A | Brandon Staley | 1st | Brandon Staley | |
| LAR | A | Sean McVay | 5th | Sean McVay | |
| MIA | A | Brian Flores | 3rd | Mike McDaniel | |
| MIN | N | Mike Zimmer | 8th | Kevin O'Connell | |
| NE | A | Bill Belichick | 22nd | Bill Belichick | |
| NO | N | Sean Payton | 16th | Dennis Allen | |
| NYG | N | Joe Judge | 2nd | Brian Daboll | |
| NYJ | A | Robert Saleh | 1st | Robert Saleh | |
| PHI | N | Nick Sirianni | 1st | Nick Sirianni | |
| PIT | A | Mike Tomlin | 15th | Mike Tomlin | |
| SF | N | Kyle Shanahan | 5th | Kyle Shanahan | |
| SEA | N | Pete Carroll | 12th | Pete Carroll | |
| TB | N | Bruce Arians | 3rd | Todd Bowles | |
| TEN | A | Mike Vrabel | 4th | Mike Vrabel | |
| WAS | N | Ron Rivera | 2nd | Ron Rivera |